N'-Hydroxy-2-methylpropanimidamide → HCID 58002443, compound

HRID 1643034Notes

Reaction equation

HRID 1643034 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([N:10]2[CH2:15][CH:14]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=3)[CH2:13][CH:12]([C:26]([OH:28])=O)[CH2:11]2)=[O:9])[CH2:4][CH2:3]1.O[N:30]=[C:31]([NH2:35])[CH:32]([CH3:34])[CH3:33]>>[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([N:10]2[CH2:15][CH:14]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:24])([F:25])[F:23])[CH:17]=3)[CH2:13][CH:12]([C:26]3[O:28][N:35]=[C:31]([CH:32]([CH3:34])[CH3:33])[N:30]=3)[CH2:11]2)=[O:9])[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 2794833N'-Hydroxy-2-methylpropanimidamideHCID 58002715HCID 58002715, compound

Product 1

HCID 58002443HCID 58002443, compound

Procedure

75 mg (0.17 mmol) of the compound from Example 150A and 27 mg (0.25 mmol) of N′-hydroxy-2-methylpropanimidamide were reacted according to the General Method 2. Yield: 26 mg (33% of theory)

Sources & evidence

ORD record
ord-6c05dcb753944f0ba0321135b747c95b
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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