HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Aminopyrrolidine dihydrochloride → (3-Aminopyrrolidin-1-yl){3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethyl)phenyl]-piperidin-1-yl}methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Aminopyrrolidine dihydrochloride | HCID 16212596 | — |
| Reactant | 4-Nitrophenyl 3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethyl)phenyl]piperidine-1-carboxylate | HCID 58002174 | — |
| Product | (3-Aminopyrrolidin-1-yl){3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethyl)phenyl]-piperidin-1-yl}methanone | HCID 58002535 | — |
Reaction Steps
100 mg (0.20 mmol) of the compound from Example 184A and 95 mg (0.60 mmol) of 3-aminopyrrolidine dihydrochloride were reacted according to the General Method 6. Yield: 25 mg (27% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-c53883f02de84efb9adf0d8a95c37e76 |
| Source note | uspto-grants-2012_02 |