HuagongsheHuagongshe Chemistry Print Report · For research reference only
N'-Hydroxy-2-methylpropanimidamide → (3-Hydroxyazetidin-1-yl) {3-[3-(propan-2-yl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethyl)phenyl]-piperidin-1-yl}methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N'-Hydroxy-2-methylpropanimidamide | HCID 2794833 | — |
| Reactant | 1-[(3-Hydroxyazetidin-1-yl)carbonyl]-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid | HCID 58002578 | — |
| Product | (3-Hydroxyazetidin-1-yl) {3-[3-(propan-2-yl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethyl)phenyl]-piperidin-1-yl}methanone | HCID 58002636 | — |
Reaction Steps
100 mg (0.269 mmol) of 1-[(3-hydroxyazetidin-1-yl)carbonyl]-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid (Example 101A) and 30.7 mg (0.295 mmol) of N′-hydroxy-2-methylpropanimidamide were reacted according to the General Method 1. Yield: 47 mg (39% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-1e0eb854aea84c6ba1bb501bf74a712a |
| Source note | uspto-grants-2012_02 |