(1E)-N'-Hydroxy-3-methoxypropanimidamide hydrochloride → HCID 58002609, compound

Participants

Reaction Steps

250 mg (0.647 mmol) of 1-[(3-methoxyazetidin-1-yl)carbonyl]-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid (Example 103A) and 112 mg (0.712 mmol, 75% pure) of N′-hydroxy-3-methoxypropanimidamide (Example 64A) were reacted according to the General Method 1. Enantiomer separation of the racemate according to Method 16D gave 67.0 mg of the title compound from Example 313 and 67.0 mg of the title compound from Example 314 (44% of theory).

Provenance & Evidence