HCID 57374593, compound → HCID 58002501, compound

HRID 1643090Notes

Reaction equation

HRID 1643090 reaction equation
[N:1]1([C:7]([N:9]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=3)[CH2:12][CH:11]([C:25](O)=[O:26])[CH2:10]2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.O[N:29]=[C:30]([C:32]1[CH:33]=[N:34][CH:35]=[CH:36][C:37]=1[CH3:38])[NH2:31]>>[CH3:38][C:37]1[CH:36]=[CH:35][N:34]=[CH:33][C:32]=1[C:30]1[N:31]=[C:25]([CH:11]2[CH2:12][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:23])([F:22])[F:24])=[CH:17][CH:16]=3)[CH2:14][N:9]([C:7]([N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)=[O:8])[CH2:10]2)[O:26][N:29]=1

Participants

3

Reactant 2

HCID 57374593HCID 57374593, compoundHCID 580024471-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid

Product 1

HCID 58002501HCID 58002501, compound

Procedure

250 mg (about 0.520 mmol) of the compound from Example 49A and 87 mg (0.580 mmol) of N′-hydroxy-4-methylpyridine-3-carboximidamide (Example 70A) were reacted according to the General Method 1. Yield: 22 mg (8% of theory).

Sources & evidence

ORD record
ord-929c4f1d051349cab95a2b4f7c4469ff
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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