Lawesson's reagent → Morpholin-4-yl {3-(5-phenyl-1,3-thiazol-2-yl)-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}methanone

Participants

Role	Name	HCID	Charge
Reactant	Lawesson's reagent	HCID 87949	—
Reactant	1-(Morpholin-4-ylcarbonyl)-N-(2-oxo-2-phenylethyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxamide	HCID 58002276	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	Morpholin-4-yl {3-(5-phenyl-1,3-thiazol-2-yl)-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}methanone	HCID 58002565	—

Reaction Conditions

Temperature	50 °C

Reaction Steps

600 mg (1.484 mmol) of Lawesson reagent were added to a solution of 300 mg (about 0.371 mmol) of the compound from Example 106A in 5 ml of dioxane. The reaction mixture was stirred at 50° C. for 5 h and, without any further purification, was purified by preparative HPLC. Yield: 5 mg (3% of theory)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08119663B2
Source dataset	uspto-grants-2012_02
ORD ID	ord-5804217033db4e008db63385cba56387
Source note	uspto-grants-2012_02