HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1E)-N'-Hydroxy-3-methoxypropanimidamide hydrochloride → {3-(4-Ethylphenyl)-5-[3-(2-methoxyethyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}(3-hydroxyazetidin-1-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1E)-N'-Hydroxy-3-methoxypropanimidamide hydrochloride | HCID 4390391 | — |
| Reactant | 5-(4-Ethylphenyl)-1-[(3-hydroxyazetidin-1-yl)carbonyl]piperidine-3-carboxylic acid | HCID 58002369 | — |
| Product | {3-(4-Ethylphenyl)-5-[3-(2-methoxyethyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}(3-hydroxyazetidin-1-yl)methanone | HCID 58002232 | — |
Reaction Steps
60 mg (0.18 mmol) of the compound from Example 138A and 43 mg (0.27 mmol) of N′-hydroxy-3-methoxypropanimidamide were reacted according to the General Method 2. Yield: 25 mg (33% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-92cd484a80c14a098e29134bb5521b12 |
| Source note | uspto-grants-2012_02 |