1-[(4-Hydroxypiperidin-1-yl)carbonyl]-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid → (4-Hydroxypiperidin-1-yl) {3-{3-[2-(propan-2-yloxy)ethyl]-1,2,4-oxadiazol-5-yl}-5-[4-(trifluoro-methyl)phenyl]piperidin-1-yl}methanone

Participants

Role	Name	HCID	Charge
Reactant	1-[(4-Hydroxypiperidin-1-yl)carbonyl]-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid	HCID 58002340	—
Reactant	N-Hydroxy-3-(1-methylethoxy)-propanimidamide	HCID 74045961	—
Product	(4-Hydroxypiperidin-1-yl) {3-{3-[2-(propan-2-yloxy)ethyl]-1,2,4-oxadiazol-5-yl}-5-[4-(trifluoro-methyl)phenyl]piperidin-1-yl}methanone	HCID 58002693	—

Reaction Steps

100 mg (0.25 mmol) of the compound from Example 99A and 61 mg (0.38 mmol) of the compound from Example 65A were reacted according to the General Method 2. Yield: 82 mg (61% of theory)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08119663B2
Source dataset	uspto-grants-2012_02
ORD ID	ord-afa2d67279614ca488b57aa097018147
Source note	uspto-grants-2012_02