N'-Hydroxycyclopropanecarboximidamide → HCID 58002429, compound

HRID 1643100Notes

Reaction equation

[CH3:1][C:2]1[CH:3]=[C:4]([CH:13]2[CH2:18][N:17]([C:19]([N:21]3[CH2:26][CH2:25][O:24][CH2:23][CH2:22]3)=[O:20])[CH2:16][CH:15]([C:27]([OH:29])=O)[CH2:14]2)[CH:5]=[CH:6][C:7]=1[O:8][C:9]([F:12])([F:11])[F:10].O[N:31]=[C:32]([CH:34]1[CH2:36][CH2:35]1)[NH2:33]>>[CH:34]1([C:32]2[N:33]=[C:27]([CH:15]3[CH2:14][CH:13]([C:4]4[CH:5]=[CH:6][C:7]([O:8][C:9]([F:12])([F:11])[F:10])=[C:2]([CH3:1])[CH:3]=4)[CH2:18][N:17]([C:19]([N:21]4[CH2:26][CH2:25][O:24][CH2:23][CH2:22]4)=[O:20])[CH2:16]3)[O:29][N:31]=2)[CH2:36][CH2:35]1

Participants

Reactant 2

HCID 2794666N'-Hydroxycyclopropanecarboximidamide

HCID 58002462HCID 58002462, compound

Product 1

HCID 58002429HCID 58002429, compound

Procedure

100 mg (0.24 mmol) of the compound from Example 167A and 36 mg (0.36 mmol) of N′-hydroxycyclopropanecarboximidamide were reacted according to the General Method 2. Yield: 72 mg (62% of theory).

Sources & evidence

ORD record: ord-e252b13120f74136972c64d4c68d8366
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08119663B2

Reaction notes

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