N'-Hydroxy-2-methylpropanimidamide → HCID 58002567, compound

HRID 1643102Notes

Reaction equation

HRID 1643102 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([N:10]2[CH2:15][CH:14]([C:16]3[CH:21]=[CH:20][C:19]([O:22][C:23]([F:26])([F:25])[F:24])=[C:18]([CH3:27])[CH:17]=3)[CH2:13][CH:12]([C:28](OC)=[O:29])[CH2:11]2)=[O:9])[CH2:4][CH2:3]1.O[N:33]=[C:34]([NH2:38])[CH:35]([CH3:37])[CH3:36]>>[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([N:10]2[CH2:11][CH:12]([C:28]3[O:29][N:38]=[C:34]([CH:35]([CH3:37])[CH3:36])[N:33]=3)[CH2:13][CH:14]([C:16]3[CH:21]=[CH:20][C:19]([O:22][C:23]([F:25])([F:24])[F:26])=[C:18]([CH3:27])[CH:17]=3)[CH2:15]2)=[O:9])[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 2794833N'-Hydroxy-2-methylpropanimidamideHCID 58002243HCID 58002243, compound

Product 1

HCID 58002567HCID 58002567, compound

Procedure

500 mg (1.12 mmol) of the compound from Example 169A and 125 mg (1.23 mmol) of N′-hydroxy-2-methylpropanimidamide were reacted according to the General Method 1. Yield: 373 mg (67% of theory).

Sources & evidence

ORD record
ord-8ae799d3834a49de966b08af1b12ec77
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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