3-fluoro-N'-hydroxybenzene-1-carboximidamide → HCID 58002727, compound

HRID 1643103Notes

Reaction equation

HRID 1643103 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][N:12]([C:14]([N:16]3[CH2:21][CH2:20][O:19][CH2:18][CH2:17]3)=[O:15])[CH2:11][CH:10]([C:22](O)=[O:23])[CH2:9]2)=[CH:4][C:3]=1[C:25]([F:28])([F:27])[F:26].[F:29][C:30]1[CH:31]=[C:32]([C:36](=[N:38]O)[NH2:37])[CH:33]=[CH:34][CH:35]=1>>[F:29][C:30]1[CH:31]=[C:32]([C:36]2[N:38]=[C:22]([CH:10]3[CH2:9][CH:8]([C:5]4[CH:6]=[CH:7][C:2]([CH3:1])=[C:3]([C:25]([F:27])([F:28])[F:26])[CH:4]=4)[CH2:13][N:12]([C:14]([N:16]4[CH2:17][CH2:18][O:19][CH2:20][CH2:21]4)=[O:15])[CH2:11]3)[O:23][N:37]=2)[CH:33]=[CH:34][CH:35]=1

Participants

3

Reactant 2

HCID 40909723-fluoro-N'-hydroxybenzene-1-carboximidamideHCID 58002297HCID 58002297, compound

Product 1

HCID 58002727HCID 58002727, compound

Procedure

100 mg (about 0.24 mmol) of the compound from Example 160A and 55 mg (0.36 mmol) of 3-fluoro-N′-hydroxybenzenecarboximidamide were reacted according to the General Method 2. Yield: 67 mg (54% of theory).

Sources & evidence

ORD record
ord-1a5c7631d33841ed9dc18d4e864f2403
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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