3-fluoro-N'-hydroxybenzene-1-carboximidamide → HCID 58002622, compound

HRID 1643104Notes

Reaction equation

HRID 1643104 reaction equation
[C:1]([CH:3]1[CH2:8][CH2:7][N:6]([C:9]([N:11]2[CH2:16][CH:15]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=3)[CH2:14][CH:13]([C:27]([OH:29])=O)[CH2:12]2)=[O:10])[CH2:5][CH2:4]1)#[N:2].[F:30][C:31]1[CH:32]=[C:33]([C:37](=[N:39]O)[NH2:38])[CH:34]=[CH:35][CH:36]=1>>[F:30][C:31]1[CH:32]=[C:33]([C:37]2[N:39]=[C:27]([CH:13]3[CH2:14][CH:15]([C:17]4[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:24])([F:25])[F:26])[CH:18]=4)[CH2:16][N:11]([C:9]([N:6]4[CH2:7][CH2:8][CH:3]([C:1]#[N:2])[CH2:4][CH2:5]4)=[O:10])[CH2:12]3)[O:29][N:38]=2)[CH:34]=[CH:35][CH:36]=1

Participants

3

Reactant 2

HCID 40909723-fluoro-N'-hydroxybenzene-1-carboximidamideHCID 58002152HCID 58002152, compound

Product 1

HCID 58002622HCID 58002622, compound

Procedure

100 mg (0.24 mmol) of the compound from Example 152A and 56 mg (0.37 mmol) of 3-fluoro-N′-hydroxybenzenecarboximidamide were reacted according to the General Method 2. Yield: 87 mg (68% of theory).

Sources & evidence

ORD record
ord-4653af1e11134706b01228beb3ccda24
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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