N'-Hydroxycyclopropanecarboximidamide → HCID 58002677, compound

HRID 1643106Notes

Reaction equation

[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([N:10]2[CH2:15][CH:14]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[C:18]([C:23]([F:26])([F:25])[F:24])[CH:17]=3)[CH2:13][CH:12]([C:27](O)=[O:28])[CH2:11]2)=[O:9])[CH2:4][CH2:3]1.O[N:31]=[C:32]([CH:34]1[CH2:36][CH2:35]1)[NH2:33]>>[CH:34]1([C:32]2[N:33]=[C:27]([CH:12]3[CH2:13][CH:14]([C:16]4[CH:21]=[CH:20][C:19]([CH3:22])=[C:18]([C:23]([F:25])([F:26])[F:24])[CH:17]=4)[CH2:15][N:10]([C:8]([N:5]4[CH2:6][CH2:7][CH:2]([OH:1])[CH2:3][CH2:4]4)=[O:9])[CH2:11]3)[O:28][N:31]=2)[CH2:36][CH2:35]1

Participants

Reactant 2

HCID 2794666N'-Hydroxycyclopropanecarboximidamide

HCID 58002260HCID 58002260, compound

Product 1

HCID 58002677HCID 58002677, compound

Procedure

100 mg (0.24 mmol) of the compound from Example 163A and 36 mg (0.36 mmol) of N′-hydroxycyclopropanecarboximidamide were reacted according to the General Method 2. Yield: 60 mg (51% of theory).

Sources & evidence

ORD record: ord-cff14dc25d924995aa656637681fcca4
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08119663B2

Reaction notes

Loading…