(1E)-N'-Hydroxy-3-methoxypropanimidamide hydrochloride → HCID 58002298, compound

HRID 1643107Notes

Reaction equation

HRID 1643107 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([N:10]2[CH2:15][CH:14]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[C:18]([C:23]([F:26])([F:25])[F:24])[CH:17]=3)[CH2:13][CH:12]([C:27]([OH:29])=O)[CH2:11]2)=[O:9])[CH2:4][CH2:3]1.O[N:31]=[C:32]([NH2:37])[CH2:33][CH2:34][O:35][CH3:36]>>[OH:1][CH:2]1[CH2:3][CH2:4][N:5]([C:8]([N:10]2[CH2:15][CH:14]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[C:18]([C:23]([F:24])([F:26])[F:25])[CH:17]=3)[CH2:13][CH:12]([C:27]3[O:29][N:37]=[C:32]([CH2:33][CH2:34][O:35][CH3:36])[N:31]=3)[CH2:11]2)=[O:9])[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 4390391(1E)-N'-Hydroxy-3-methoxypropanimidamide hydrochlorideHCID 58002260HCID 58002260, compound

Product 1

HCID 58002298HCID 58002298, compound

Procedure

200 mg (0.48 mmol) of the compound from Example 163A and 114 mg (0.72 mmol) of t-hydroxy -3-methoxypropanimidamide (Example 64A) were reacted according to the General Method 2. Yield: 105 mg (44% of theory).

Sources & evidence

ORD record
ord-8fb102cffb4941b8bb0425eff52200cb
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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