HuagongsheHuagongshe Chemistry Print Report · For research reference only
N'-Hydroxy-2-methylpropanimidamide → (3-Hydroxypyrrolidin-1-yl) {3-[3-(propan-2-yl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethoxy)-phenyl]piperidin-1-yl}methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N'-Hydroxy-2-methylpropanimidamide | HCID 2794833 | — |
| Reactant | 1-[(3-Hydroxypyrrolidin-1-yl)carbonyl]-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid | HCID 58002490 | — |
| Product | (3-Hydroxypyrrolidin-1-yl) {3-[3-(propan-2-yl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethoxy)-phenyl]piperidin-1-yl}methanone | HCID 58002175 | — |
Reaction Steps
200 mg (0.50 mmol) of the compound from Example 112A and 76 mg (0.75 mmol) of N′-hydroxy-2-methylpropanimidamide were reacted according to the General Method 2. Yield: 125 mg (54% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-b2ab296990064a99bc2bc74180651541 |
| Source note | uspto-grants-2012_02 |