(1E)-N'-Hydroxy-3-methoxypropanimidamide hydrochloride → (3-Hydroxypyrrolidin-1-yl) {3-[3-(2-methoxyethyl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethoxy)-phenyl]piperidin-1-yl}methanone

Participants

Role	Name	HCID	Charge
Reactant	(1E)-N'-Hydroxy-3-methoxypropanimidamide hydrochloride	HCID 4390391	—
Reactant	1-[(3-Hydroxypyrrolidin-1-yl)carbonyl]-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid	HCID 58002490	—
Product	(3-Hydroxypyrrolidin-1-yl) {3-[3-(2-methoxyethyl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethoxy)-phenyl]piperidin-1-yl}methanone	HCID 58002199	—

Reaction Steps

200 mg (0.50 mmol) of the compound from Example 112A and 88 mg (0.75 mmol) of N′-hydroxy-3-methoxypropanimidamide were reacted according to the General Method 2. Yield: 67 mg (27% of theory).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08119663B2
Source dataset	uspto-grants-2012_02
ORD ID	ord-068fa7bda67540a6958e1377e0dc51d5
Source note	uspto-grants-2012_02