HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Hydroxypropionimidamide → {3-(3-Ethyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}(3-hydroxypyrrolidin-1-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Hydroxypropionimidamide | HCID 4092053 | — |
| Reactant | 1-[(3-Hydroxypyrrolidin-1-yl)carbonyl]-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid | HCID 58002490 | — |
| Product | {3-(3-Ethyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}(3-hydroxypyrrolidin-1-yl)methanone | HCID 58002124 | — |
Reaction Steps
200 mg (0.50 mmol) of the compound from Example 112A and 67 mg (0.75 mmol) of N′-hydroxypropanimidamide were reacted according to the General Method 2. Yield: 17 mg (7% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-f909706dcaab4e39ac9cb2db7fbf84ef |
| Source note | uspto-grants-2012_02 |