HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Hydroxyacetamidine → (3-Hydroxypyrrolidin-1-yl) {3-(3-methyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethoxy)phenyl]-piperidin-1-yl}methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Hydroxyacetamidine | HCID 30926 | — |
| Reactant | 1-[(3-Hydroxypyrrolidin-1-yl)carbonyl]-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid | HCID 58002490 | — |
| Product | (3-Hydroxypyrrolidin-1-yl) {3-(3-methyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethoxy)phenyl]-piperidin-1-yl}methanone | HCID 58002172 | — |
Reaction Steps
200 mg (0.50 mmol) of the compound from Example 112A and 55 mg (0.75 mmol) of N′-hydroxyethanimidamide were reacted according to the General Method 2. Yield: 15 mg (6% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-2b3cada3219245069d86eac5b566783e |
| Source note | uspto-grants-2012_02 |