5-(4-Ethylphenyl)-1-(morpholin-4-ylcarbonyl)-N-(prop-2-yn-1-yl)piperidine-3-carboxamide → [3-(4-Ethylphenyl)-5-(5-methyl-1,3-oxazol-2-yl)piperidin-1-yl](morpholin-4-yl)methanone

Participants

Reaction Conditions

Reaction Steps

50 mg (0.13 mmol) of the compound from Example 199A were initially charged in 0.5 ml of acetonitrile, and 2 mg (0.01 mmol) of gold trichloride were added. The reaction mixture was stirred at 50° C. for 16 h, concentrated and purified by preparative HPLC. Yield: 10 mg (15% of theory).

Provenance & Evidence