2-Methylpropanehydrazide → HCID 58002337, compound

HRID 1643123Notes

Reaction equation

HRID 1643123 reaction equation
[N:1]1([C:7]([N:9]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=3)[CH2:12][CH:11]([C:26](O)=[O:27])[CH2:10]2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH3:29][CH:30]([CH3:35])[C:31]([NH:33][NH2:34])=O>>[N:1]1([C:7]([N:9]2[CH2:14][CH:13]([C:15]3[CH:16]=[CH:17][C:18]([O:21][C:22]([F:23])([F:24])[F:25])=[CH:19][CH:20]=3)[CH2:12][CH:11]([C:26]3[O:27][C:31]([CH:30]([CH3:35])[CH3:29])=[N:33][N:34]=3)[CH2:10]2)=[O:8])[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 192392-MethylpropanehydrazideHCID 580025001-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid

Product 1

HCID 58002337HCID 58002337, compound

Procedure

100 mg the compound from Example 44A and 28 mg (0.273 mmol) of 2-methylpropanehydrazide were reacted according to the General Method 4. Yield: 45 mg (39% of theory).

Sources & evidence

ORD record
ord-14689c3b4a7e48e98fc126dab6174264
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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