Ethyl 3-hydrazino-3-oxopropionate → HCID 58002289, compound

HRID 1643124Notes

Reaction equation

HRID 1643124 reaction equation
[N:1]1([C:7]([N:9]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=3)[CH2:12][CH:11]([C:26](O)=O)[CH2:10]2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[NH:29]([C:31](=[O:38])[CH2:32][C:33]([O:35][CH2:36][CH3:37])=[O:34])[NH2:30]>>[N:1]1([C:7]([N:9]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:23])[F:24])=[CH:17][CH:16]=3)[CH2:12][CH:11]([C:26]3[O:38][C:31]([CH2:32][C:33]([O:35][CH2:36][CH3:37])=[O:34])=[N:29][N:30]=3)[CH2:10]2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 252897Ethyl 3-hydrazino-3-oxopropionateHCID 580025001-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid

Product 1

HCID 58002289HCID 58002289, compound

Procedure

100 mg (0.249 mmol) of the compound from Example 44A and 40 mg (0.273 mmol) of ethyl 3-hydrazinyl-3-oxopropanoate were reacted according to the General Method 4. Yield: 9 mg (6% of theory).

Sources & evidence

ORD record
ord-b1f97507044f440db3a8370ba4d327d6
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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