3-Chlorobenzohydrazide → HCID 58002506, compound

HRID 1643126Notes

Reaction equation

HRID 1643126 reaction equation
[N:1]1([C:7]([N:9]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=3)[CH2:12][CH:11]([C:25](O)=[O:26])[CH2:10]2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Cl:28][C:29]1[CH:30]=[C:31]([C:35]([NH:37][NH2:38])=O)[CH:32]=[CH:33][CH:34]=1>>[Cl:28][C:29]1[CH:30]=[C:31]([C:35]2[O:26][C:25]([CH:11]3[CH2:12][CH:13]([C:15]4[CH:16]=[CH:17][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:19][CH:20]=4)[CH2:14][N:9]([C:7]([N:1]4[CH2:2][CH2:3][O:4][CH2:5][CH2:6]4)=[O:8])[CH2:10]3)=[N:38][N:37]=2)[CH:32]=[CH:33][CH:34]=1

Participants

3

Reactant 2

HCID 742893-ChlorobenzohydrazideHCID 580024471-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid

Product 1

HCID 58002506HCID 58002506, compound

Procedure

200 mg (0.518 mmol) of the compound from Example 49A and 97 mg (0.569 mmol) of 3-chlorobenzenecarbohydrazide were reacted according to the General Method 4. Yield: 13 mg (11% of theory).

Sources & evidence

ORD record
ord-cd4a14f86c2b4a91afebd230f604c6a3
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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