HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-4-methyl-2-pentanone → {3-[4-(2-Methylpropyl)-1,3-thiazol-2-yl]-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}(morpholin-4-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-4-methyl-2-pentanone | HCID 11084464 | — |
| Reactant | 1-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carbothioamide | HCID 58002394 | — |
| Product | {3-[4-(2-Methylpropyl)-1,3-thiazol-2-yl]-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}(morpholin-4-yl)methanone | HCID 58002179 | — |
Reaction Steps
100 mg (about 0.182 mmol) of the compound from Example 115A and 49 mg (0.273 mmol) of 1-bromo-4-methylpentan-2-one (J. Org. Chem., 19, 2005, 4141-4153) were reacted according to the General Method 3. Yield: 50 mg (55% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-d52b859ab1d247a2910f8a81b0daf10d |
| Source note | uspto-grants-2012_02 |