HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-cyclopropylethan-1-one → {3-(4-Cyclopropyl-1,3-thiazol-2-yl)-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}(morpholin-4-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-cyclopropylethan-1-one | HCID 10920841 | — |
| Reactant | 1-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carbothioamide | HCID 58002394 | — |
| Product | {3-(4-Cyclopropyl-1,3-thiazol-2-yl)-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}(morpholin-4-yl)methanone | HCID 58002217 | — |
Reaction Steps
100 mg (about 0.182 mmol) of the compound from Example 115A and 44 mg (0.273 mmol) of 2-bromo-1-cyclopropylethanone (Tetrahedron, 43, 20 1987, 4609-4619) were reacted according to the General Method 3. Yield: 49 mg (56% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-c94848eeb1d44b5ea3cddffc274eac55 |
| Source note | uspto-grants-2012_02 |