Bromopinacolone → {3-(4-tert-Butyl-1,3-thiazol-2-yl)-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}(morpholin-4-yl)-methanone
Reaction equation
[N:1]1([C:7]([N:9]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=3)[CH2:12][CH:11]([C:26](=[S:28])[NH2:27])[CH2:10]2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Br[CH2:30][C:31](=O)[C:32]([CH3:35])([CH3:34])[CH3:33]>>[C:32]([C:31]1[N:27]=[C:26]([CH:11]2[CH2:12][CH:13]([C:15]3[CH:16]=[CH:17][C:18]([O:21][C:22]([F:23])([F:24])[F:25])=[CH:19][CH:20]=3)[CH2:14][N:9]([C:7]([N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)=[O:8])[CH2:10]2)[S:28][CH:30]=1)([CH3:35])([CH3:34])[CH3:33]Participants
3
Procedure
100 mg (about 0.182 mmol) of the compound from Example 115A and 49 mg (0.273 mmol) of 1-bromo-3,3-dimethylbutan-2-one were reacted according to the General Method 3. Yield: 56 mg (59% of theory).
Sources & evidence
- ORD record
- ord-907f09ed8b5044159b542b8b0597f108
- Source dataset
- uspto-grants-2012_02
- Patent number
- US08119663B2
Reaction notes
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