HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluorophenacyl bromide → {3-[4-(3-Fluorophenyl)-1,3-thiazol-2-yl]-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}(morpholin-4-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluorophenacyl bromide | HCID 2737451 | — |
| Reactant | 1-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carbothioamide | HCID 58002394 | — |
| Product | {3-[4-(3-Fluorophenyl)-1,3-thiazol-2-yl]-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}(morpholin-4-yl)methanone | HCID 58002153 | — |
Reaction Steps
100 mg (about 0.211 mmol) of the compound from Example 115A and 55 mg (0.253 mmol) of 2-bromo-1-(3-fluorophenyl)ethanone were reacted according to the General Method 3. Yield: 78 mg (69% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-4f7db52d82694e36a022b5fe54ae1381 |
| Source note | uspto-grants-2012_02 |