HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-2-butanone → {3-(4-Ethyl-1,3-thiazol-2-yl)-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}(morpholin-4-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-2-butanone | HCID 13156 | — |
| Reactant | 1-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carbothioamide | HCID 58002394 | — |
| Product | {3-(4-Ethyl-1,3-thiazol-2-yl)-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}(morpholin-4-yl)-methanone | HCID 58002214 | — |
Reaction Steps
100 mg (about 0.211 mmol) of the compound from Example 115A and 38 mg (0.253 mmol) of 1-bromobutan-2-one were reacted according to the General Method 3. Yield: 49 mg (47% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-c02ed2ce77cb496ba4af7034ac6cca5c |
| Source note | uspto-grants-2012_02 |