Bromopinacolone → HCID 58002637, compound

HRID 1643141Notes

Reaction equation

[C:1]([CH:3]1[CH2:8][CH2:7][N:6]([C:9]([N:11]2[CH2:16][CH:15]([C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]([F:27])([F:26])[F:25])=[CH:19][CH:18]=3)[CH2:14][CH:13]([C:28](=[S:30])[NH2:29])[CH2:12]2)=[O:10])[CH2:5][CH2:4]1)#[N:2].Br[CH2:32][C:33](=O)[C:34]([CH3:37])([CH3:36])[CH3:35]>>[C:34]([C:33]1[N:29]=[C:28]([CH:13]2[CH2:14][CH:15]([C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]([F:26])([F:25])[F:27])=[CH:19][CH:18]=3)[CH2:16][N:11]([C:9]([N:6]3[CH2:5][CH2:4][CH:3]([C:1]#[N:2])[CH2:8][CH2:7]3)=[O:10])[CH2:12]2)[S:30][CH:32]=1)([CH3:37])([CH3:36])[CH3:35]

Participants

Reactant 2

HCID 21642Bromopinacolone

HCID 58002347HCID 58002347, compound

Product 1

HCID 58002637HCID 58002637, compound

Procedure

200 mg (about 0.204 mmol) of the compound from Example 117A and 55 mg (0.300 mmol) of 1-bromo-3,3-dimethylbutan-2-one were reacted according to the General Method 3. Yield: 43 mg (40% of theory).

Sources & evidence

ORD record: ord-54931054895845a7b0988c70356eddae
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08119663B2

Reaction notes

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