Lawesson's reagent → {3-(5-Methyl-1,3,4-thiadiazol-2-yl)-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}(morpholin-4-yl)-methanone

HRID 1643143Notes

Reaction equation

HRID 1643143 reaction equation
[C:1]([NH:4][NH:5][C:6]([CH:8]1[CH2:13][CH:12]([C:14]2[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=2)[CH2:11][N:10]([C:25]([N:27]2[CH2:32][CH2:31][O:30][CH2:29][CH2:28]2)=[O:26])[CH2:9]1)=O)(=O)[CH3:2].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:42])=CC=1>>[CH3:2][C:1]1[S:42][C:6]([CH:8]2[CH2:13][CH:12]([C:14]3[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=3)[CH2:11][N:10]([C:25]([N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)=[O:26])[CH2:9]2)=[N:5][N:4]=1

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 58002704N'-Acetyl-1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carbohydrazide

Product 1

HCID 58002279{3-(5-Methyl-1,3,4-thiadiazol-2-yl)-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}(morpholin-4-yl)-methanone

Procedure

106 mg (0.231 mmol) of the compound from Example 121A and 187 mg (0.462 mmol) of Lawesson reagent were reacted according to the General Method 9. Yield: 10 mg (10% of theory)

Sources & evidence

ORD record
ord-0ea480e995234ff88a9b38b27a37eaab
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

Loading…