HCID 58002494, compound → HCID 58002465, compound

HRID 1643146Notes

Reaction equation

HRID 1643146 reaction equation
[CH3:1][O:2][CH:3]1[CH2:6][N:5]([C:7]([N:9]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=3)[CH2:12][CH:11]([C:25]([OH:27])=O)[CH2:10]2)=[O:8])[CH2:4]1.Cl.O[N:30]=[C:31]([NH2:34])[CH2:32][CH3:33]>>[CH2:32]([C:31]1[N:34]=[C:25]([CH:11]2[CH2:12][CH:13]([C:15]3[CH:16]=[CH:17][C:18]([C:21]([F:23])([F:22])[F:24])=[CH:19][CH:20]=3)[CH2:14][N:9]([C:7]([N:5]3[CH2:4][CH:3]([O:2][CH3:1])[CH2:6]3)=[O:8])[CH2:10]2)[O:27][N:30]=1)[CH3:33]

Participants

3

Reactant 2

HCID 58002494HCID 58002494, compoundHCID 73010663HCID 73010663, compound

Product 1

HCID 58002465HCID 58002465, compound

Procedure

250 mg (0.647 mmol) of 1-[(3-methoxyazetidin-1-yl)carbonyl]-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid (Example 103A) and 88.7 mg (0.712 mmol) of N′-hydroxypropanimidamide hydrochloride were reacted according to the General Method 1. Yield: 151 mg (52% of theory).

Sources & evidence

ORD record
ord-f9723a9db17a475face274173c7d5d5c
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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