HCID 58002503, compound → HCID 58002481, compound

HRID 1643147Notes

Reaction equation

HRID 1643147 reaction equation
[CH3:1][O:2][CH:3]1[CH2:8][CH2:7][CH2:6][N:5]([C:9]([N:11]2[CH2:16][CH:15]([C:17]3[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=3)[CH2:14][CH:13]([C:27]([OH:29])=O)[CH2:12]2)=[O:10])[CH2:4]1.Cl.O[N:32]=[C:33]([NH2:36])[CH2:34][CH3:35]>>[CH2:34]([C:33]1[N:36]=[C:27]([CH:13]2[CH2:14][CH:15]([C:17]3[CH:18]=[CH:19][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:21][CH:22]=3)[CH2:16][N:11]([C:9]([N:5]3[CH2:6][CH2:7][CH2:8][CH:3]([O:2][CH3:1])[CH2:4]3)=[O:10])[CH2:12]2)[O:29][N:32]=1)[CH3:35]

Participants

3

Reactant 2

HCID 58002503HCID 58002503, compoundHCID 73010663HCID 73010663, compound

Product 1

HCID 58002481HCID 58002481, compound

Procedure

250 mg (0.434 mmol, 72% pure) of 1-[(3-methoxypiperidin-1-yl)carbonyl]-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid (Example 207A) and 59.5 mg (0.712 mmol) of N′-hydroxypropanimidamide hydrochloride were reacted according to the General Method 1. Yield: 93.9 mg (46% of theory).

Sources & evidence

ORD record
ord-e7d52518ed614075870eecc851751ba8
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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