N'-Hydroxy-2-methylpropanimidamide → HCID 58002355, compound

HRID 1643151Notes

Reaction equation

HRID 1643151 reaction equation
[O:1]=[C:2]1[NH:7][CH2:6][CH2:5][N:4]([C:8]([N:10]2[CH2:15][CH:14]([C:16]3[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=3)[CH2:13][CH:12]([C:26](O)=[O:27])[CH2:11]2)=[O:9])[CH2:3]1.O[N:30]=[C:31]([NH2:35])[CH:32]([CH3:34])[CH3:33]>>[CH3:33][CH:32]([C:31]1[N:35]=[C:26]([CH:12]2[CH2:13][CH:14]([C:16]3[CH:21]=[CH:20][C:19]([C:22]([F:24])([F:25])[F:23])=[CH:18][CH:17]=3)[CH2:15][N:10]([C:8]([N:4]3[CH2:5][CH2:6][NH:7][C:2](=[O:1])[CH2:3]3)=[O:9])[CH2:11]2)[O:27][N:30]=1)[CH3:34]

Participants

3

Reactant 2

HCID 2794833N'-Hydroxy-2-methylpropanimidamideHCID 58002437HCID 58002437, compound

Product 1

HCID 58002355HCID 58002355, compound

Procedure

250 mg (0.626 mmol) of 1-[(3-oxopiperazin-1-yl)carbonyl]-5-[4-(trifluoromethyl)phenyl]-piperidine-3-carboxylic acid (Example 206A) and 70.3 mg (0.689 mmol) of N′-hydroxy-2-methylpropanimidamide were reacted according to the General Method 1. Yield: 190 mg (62% of theory).

Sources & evidence

ORD record
ord-aa33cb44c50e4fccbbb536125ec010aa
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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