N'-Hydroxy-2-methylpropanimidamide → HCID 58002241, compound

HRID 1643152Notes

Reaction equation

HRID 1643152 reaction equation
[CH3:1][C:2]1([CH3:29])[O:7][CH2:6][CH2:5][N:4]([C:8]([N:10]2[CH2:15][CH:14]([C:16]3[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=3)[CH2:13][CH:12]([C:26](O)=[O:27])[CH2:11]2)=[O:9])[CH2:3]1.O[N:31]=[C:32]([NH2:36])[CH:33]([CH3:35])[CH3:34]>>[CH3:29][C:2]1([CH3:1])[O:7][CH2:6][CH2:5][N:4]([C:8]([N:10]2[CH2:15][CH:14]([C:16]3[CH:17]=[CH:18][C:19]([C:22]([F:23])([F:24])[F:25])=[CH:20][CH:21]=3)[CH2:13][CH:12]([C:26]3[O:27][N:36]=[C:32]([CH:33]([CH3:35])[CH3:34])[N:31]=3)[CH2:11]2)=[O:9])[CH2:3]1

Participants

3

Reactant 2

HCID 2794833N'-Hydroxy-2-methylpropanimidamideHCID 58002698HCID 58002698, compound

Product 1

HCID 58002241HCID 58002241, compound

Procedure

250 mg (0.410 mmol, 68% pure) of 1-[(2,2-dimethylmorpholin-4-yl)carbonyl]-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid (Example 208A) and 46.1 mg (0.451 mmol) of N′-hydroxy-2-methylpropanimidamide were reacted according to the General Method 1. Yield: 118 mg (59% of theory).

Sources & evidence

ORD record
ord-4519118cc9404e9e90d958e973819abc
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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