HCID 58002388, compound → HCID 58002471, compound

HRID 1643155Notes

Reaction equation

HRID 1643155 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]([N:10]2[CH2:15][CH:14]([C:16]3[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=3)[CH2:13][CH:12]([C:26]([OH:28])=O)[CH2:11]2)=[O:9])[CH2:4][C:3]1=[O:29].Cl.O[N:32]=[C:33]([NH2:36])[CH2:34][CH3:35]>>[CH2:34]([C:33]1[N:36]=[C:26]([CH:12]2[CH2:13][CH:14]([C:16]3[CH:17]=[CH:18][C:19]([C:22]([F:24])([F:23])[F:25])=[CH:20][CH:21]=3)[CH2:15][N:10]([C:8]([N:5]3[CH2:6][CH2:7][N:2]([CH3:1])[C:3](=[O:29])[CH2:4]3)=[O:9])[CH2:11]2)[O:28][N:32]=1)[CH3:35]

Participants

3

Reactant 2

HCID 58002388HCID 58002388, compoundHCID 73010663HCID 73010663, compound

Product 1

HCID 58002471HCID 58002471, compound

Procedure

250 mg (0.605 mmol) of 1-[(4-methyl-3-oxopiperazin-1-yl)carbonyl]-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid (Example 209A) and 82.9 mg (0.665 mmol) of N′-hydroxypropanimidamide hydrochloride were reacted according to the General Method 1. Yield: 110 mg (39% of theory).

Sources & evidence

ORD record
ord-5d12555708484675912f1f90021404e0
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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