HuagongsheHuagongshe Chemistry Print Report · For research reference only
N'-hydroxy-2-methoxyethanimidamide → (3-Hydroxypyrrolidin-1-yl) {3-[3-(methoxymethyl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethoxy)-phenyl]piperidin-1-yl}methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N'-hydroxy-2-methoxyethanimidamide | HCID 4126736 | — |
| Reactant | 1-[(3-Hydroxypyrrolidin-1-yl)carbonyl]-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid | HCID 58002490 | — |
| Product | (3-Hydroxypyrrolidin-1-yl) {3-[3-(methoxymethyl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethoxy)-phenyl]piperidin-1-yl}methanone | HCID 58002129 | — |
Reaction Steps
200 mg (0.497 mmol) of the compound from Example 112A and 77 mg (0.746 mmol) of N′-hydroxy-2-methoxyethanimidamide were reacted according to the General Method 2. Yield: 55 mg (24% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-29b2f932e1a64eeba8f8fa93eb0a7919 |
| Source note | uspto-grants-2012_02 |