N'-hydroxycyclobutanecarboximidamide → HCID 58002122, compound

HRID 1643158Notes

Reaction equation

HRID 1643158 reaction equation
[N:1]1([C:7]([N:9]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=3)[CH2:12][CH:11]([C:26]([OH:28])=O)[CH2:10]2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.O[N:30]=[C:31]([CH:33]1[CH2:36][CH2:35][CH2:34]1)[NH2:32]>>[CH:33]1([C:31]2[N:32]=[C:26]([CH:11]3[CH2:12][CH:13]([C:15]4[CH:20]=[CH:19][C:18]([O:21][C:22]([F:23])([F:25])[F:24])=[CH:17][CH:16]=4)[CH2:14][N:9]([C:7]([N:1]4[CH2:6][CH2:5][O:4][CH2:3][CH2:2]4)=[O:8])[CH2:10]3)[O:28][N:30]=2)[CH2:36][CH2:35][CH2:34]1

Participants

3

Reactant 2

HCID 3413554N'-hydroxycyclobutanecarboximidamideHCID 580025001-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid

Product 1

HCID 58002122HCID 58002122, compound

Procedure

150 mg (0.373 mmol) of the compound from Example 44A and 85 mg (0.746 mmol) of N′-hydroxycyclobutanecarboximidamide were reacted according to the General Method 2. Yield: 58 mg (48% of theory)

Sources & evidence

ORD record
ord-cafbb32627da46609f0980ad6edf0468
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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