HuagongsheHuagongshe Chemistry Print Report · For research reference only
N'-Hydroxycyclopropanecarboximidamide → 1-({3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}-carbonyl)piperidine-4-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N'-Hydroxycyclopropanecarboximidamide | HCID 2794666 | — |
| Reactant | 1-[(4-Cyanopiperidin-1-yl)carbonyl]-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid | HCID 58002706 | — |
| Product | 1-({3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}-carbonyl)piperidine-4-carbonitrile | HCID 58002352 | — |
Reaction Steps
100 mg (about 0.153 mmol) of the compound from Example 108A and 30 mg (0.306 mmol) of N′-hydroxycyclopropanecarboximidamide were reacted according to the General Method 2. Yield: 312 mg (41% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-42bd2f3eb49e4b3fb8515131888daf54 |
| Source note | uspto-grants-2012_02 |