(1E)-N'-Hydroxy-3-methoxypropanimidamide hydrochloride → 1-({3-[3-(2-Methoxyethyl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}-carbonyl)piperidine-4-carbonitrile

Participants

Role	Name	HCID	Charge
Reactant	(1E)-N'-Hydroxy-3-methoxypropanimidamide hydrochloride	HCID 4390391	—
Reactant	1-[(4-Cyanopiperidin-1-yl)carbonyl]-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid	HCID 58002706	—
Product	1-({3-[3-(2-Methoxyethyl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}-carbonyl)piperidine-4-carbonitrile	HCID 58002250	—

Reaction Steps

100 mg (about 0.153 mmol) of the compound from Example 108A and 36 mg (0.306 mmol) of N′-hydroxy-3-methoxypropanimidamide were reacted according to the General Method 2. Yield: 14 mg (18% of theory)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08119663B2
Source dataset	uspto-grants-2012_02
ORD ID	ord-c776f5825c8f4d93b3284a173b2bc5cd
Source note	uspto-grants-2012_02