N'-Hydroxy-2-methylpropanimidamide → HCID 58002623, compound

HRID 1643165Notes

Reaction equation

HRID 1643165 reaction equation
[C:1]([CH:3]1[CH2:8][CH2:7][N:6]([C:9]([N:11]2[CH2:16][CH:15]([C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]([F:27])([F:26])[F:25])=[CH:19][CH:18]=3)[CH2:14][CH:13]([C:28]([OH:30])=O)[CH2:12]2)=[O:10])[CH2:5][CH2:4]1)#[N:2].O[N:32]=[C:33]([NH2:37])[CH:34]([CH3:36])[CH3:35]>>[CH3:35][CH:34]([C:33]1[N:37]=[C:28]([CH:13]2[CH2:14][CH:15]([C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]([F:25])([F:27])[F:26])=[CH:19][CH:18]=3)[CH2:16][N:11]([C:9]([N:6]3[CH2:7][CH2:8][CH:3]([C:1]#[N:2])[CH2:4][CH2:5]3)=[O:10])[CH2:12]2)[O:30][N:32]=1)[CH3:36]

Participants

3

Reactant 2

HCID 2794833N'-Hydroxy-2-methylpropanimidamideHCID 580027061-[(4-Cyanopiperidin-1-yl)carbonyl]-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid

Product 1

HCID 58002623HCID 58002623, compound

Procedure

100 mg (about 0.153 mmol) of the compound from Example 108A and 31 mg (0.306 mmol) of N′-hydroxy-2-methylpropanimidamide were reacted according to the General Method 2. Yield: 60 mg (80% of theory)

Sources & evidence

ORD record
ord-e53fae84ebe447ccb10334f1c544ca92
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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