3-fluoro-N'-hydroxybenzene-1-carboximidamide → HCID 58002362, compound

HRID 1643166Notes

Reaction equation

HRID 1643166 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][NH:5][C:6]([N:8]1[CH2:13][CH:12]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)[CH2:11][CH:10]([C:24]([OH:26])=O)[CH2:9]1)=[O:7].[F:27][C:28]1[CH:29]=[C:30]([C:34](=[N:36]O)[NH2:35])[CH:31]=[CH:32][CH:33]=1>>[F:27][C:28]1[CH:29]=[C:30]([C:34]2[N:36]=[C:24]([CH:10]3[CH2:11][CH:12]([C:14]4[CH:15]=[CH:16][C:17]([C:20]([F:21])([F:23])[F:22])=[CH:18][CH:19]=4)[CH2:13][N:8]([C:6]([NH:5][CH2:4][CH2:3][O:2][CH3:1])=[O:7])[CH2:9]3)[O:26][N:35]=2)[CH:31]=[CH:32][CH:33]=1

Participants

3

Reactant 2

HCID 40909723-fluoro-N'-hydroxybenzene-1-carboximidamideHCID 58002436HCID 58002436, compound

Product 1

HCID 58002362HCID 58002362, compound

Procedure

100 mg (0.267 mmol) of the compound from Example 105A and 77 mg (0.497 mmol) of 3-fluoro-N′-hydroxybenzenecarboximidamide were reacted according to the General Method 2. Yield: 64 mg (55% of theory)

Sources & evidence

ORD record
ord-5ef58602669b41bb939b1a48022a6805
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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