N'-Hydroxy-2-methylpropanimidamide → HCID 58002213, compound

HRID 1643171Notes

Reaction equation

HRID 1643171 reaction equation
[OH:1][CH:2]1[CH2:5][N:4]([C:6]([N:8]2[CH2:13][CH:12]([C:14]3[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=3)[CH2:11][CH:10]([C:25]([OH:27])=O)[CH2:9]2)=[O:7])[CH2:3]1.O[N:29]=[C:30]([NH2:34])[CH:31]([CH3:33])[CH3:32]>>[OH:1][CH:2]1[CH2:5][N:4]([C:6]([N:8]2[CH2:13][CH:12]([C:14]3[CH:15]=[CH:16][C:17]([O:20][C:21]([F:23])([F:24])[F:22])=[CH:18][CH:19]=3)[CH2:11][CH:10]([C:25]3[O:27][N:34]=[C:30]([CH:31]([CH3:33])[CH3:32])[N:29]=3)[CH2:9]2)=[O:7])[CH2:3]1

Participants

3

Reactant 2

HCID 2794833N'-Hydroxy-2-methylpropanimidamideHCID 58002525HCID 58002525, compound

Product 1

HCID 58002213HCID 58002213, compound

Procedure

185 mg (about 0.400 mmol) of the compound from Example 110A and 55 mg (0.600 mmol) of N′-hydroxy-2-methylpropanimidamide were reacted according to the General Method 2. Yield: 28 mg (16% of theory)

Sources & evidence

ORD record
ord-33a24d867f43473baf5a0fbcbf309d31
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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