N-Hydroxyacetamidine → HCID 58002702, compound

HRID 1643172Notes

Reaction equation

[OH:1][CH:2]1[CH2:5][N:4]([C:6]([N:8]2[CH2:13][CH:12]([C:14]3[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=3)[CH2:11][CH:10]([C:25](O)=[O:26])[CH2:9]2)=[O:7])[CH2:3]1.O[N:29]=[C:30]([NH2:32])[CH3:31]>>[OH:1][CH:2]1[CH2:3][N:4]([C:6]([N:8]2[CH2:13][CH:12]([C:14]3[CH:15]=[CH:16][C:17]([O:20][C:21]([F:22])([F:23])[F:24])=[CH:18][CH:19]=3)[CH2:11][CH:10]([C:25]3[O:26][N:32]=[C:30]([CH3:31])[N:29]=3)[CH2:9]2)=[O:7])[CH2:5]1

Participants

Reactant 2

HCID 30926N-Hydroxyacetamidine

HCID 58002525HCID 58002525, compound

Product 1

HCID 58002702HCID 58002702, compound

Procedure

185 mg (about 0.400 mmol) of the compound from Example 110A and 55 mg (0.600 mmol) of N′-hydroxyethanimidamide were reacted according to the General Method 2. Yield: 16 mg (9% of theory)

Sources & evidence

ORD record: ord-885dbf106ee04d1ebebd80c61f5e0642
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08119663B2

Reaction notes

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