HCID 86639744, compound → HCID 86639745, compound

Participants

Reaction Steps

In a mixture of hexane (10 mL) and dichloromethane (10 mL) was dissolved 4,4-bis(3,5-di-t-butyl-4-hydroxyphenylthio)pentanoic acid (600 mg, 1.04 mmol). Manganese dioxide (600 mg) was added to the resulting solution, and the resulting mixture was stirred overnight. The reaction mixture was filtered by using a celite, and the resulting filtrate was concentrated. The residue obtained by the concentration was purified by a flash column chromatography (filler: manufactured by Kanto Kagaku, K.K., 60Nmesh40-100, developing solvent:n-hexane/ethyl acetate (volume ratio)=1/0 to 2/1) to give an objective compound (yield 355 mg and 59%).

Provenance & Evidence