HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(3,4-Dichlorophenyl)ethanethioamide → Trifluoroacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(3,4-Dichlorophenyl)ethanethioamide | HCID 21504264 | — |
| Reactant | Water TFA acetonitrile | HCID 22145617 | — |
| Reactant | 2-bromo-1-(4-(4-methyl-1H-imidazol-1-yl)phenyl)ethanone | HCID 25067305 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Trifluoroacetic acid | HCID 6422 | — |
| Product | 2-(3,4-Dichloro-benzyl)-4-[4-(4-methyl-imidazole-1-yl)-phenyl]-thiazole | HCID 58911027 | — |
Reaction Steps
The thioacetamide 1213 (0.08 mmol) and 2-bromo-1-[4-(4-methyl-imidazole-1-yl)-phenyl]-ethanone (0.08 mmol) 10 were dissolved in 1 ml DMF. The reaction was stirred at 70 C for 6 hours. After cooling to room temperature, the reaction mixture was directly injected into a reversed phase HPLC (Gilson 215) using acetonitrile/water/TFA gradient and C18 stationary phase to isolate and then concentrate to give the title product 1214 as a TFA salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119680B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-be35e502436c487bb3ddc259354970bb |
| Source note | uspto-grants-2012_02 |