反应详情

To the solution of (3S,5R)-3-butyl-5-(4-fluorophenyl)dihydrofuran-2(3H)-one (94.0 mg, 0.40 mmol) in 5 mL dioxane was added 5 mL aqueous 5% KOH at 25° C. After being stirred for 30 min at room temperature the reaction was quenched by the addition of 6 mL of 1M aqueous HCl. The mixture was extracted ethyl acetate (2×10 mL) and the combined organic layers were washed with brine (2×10 mL) before being concentrated under reduced pressure. The crude product was used directly in the next reaction without further purification.

1. customwas quenched by the addition of 6 mL of 1M aqueous HCl
2. extractionThe mixture was extracted ethyl acetate (2×10 mL)
3. washthe combined organic layers were washed with brine (2×10 mL)
4. concentrationbefore being concentrated under reduced pressure
5. customThe crude product was used directly in the next reaction without further purification