反应详情

(S)-Methyl 2-((R)-2-(4-fluoro-3-methylphenyl)-2-methoxyethyl)pent-4-enoate (50 mg) was dissolved into 1 mL of a mixture of THF, methanol, and 50% NH2OH in H2O (2:2:1) and to this solution was added 2 mg KCN. The reaction was stirred for 3 days at room temperature and then quenched by the addition of 1M HCl (10 mL). The mixture was extracted with ethyl acetate (3×20 mL). The combined organic layers were washed with brine (2×10 mL) before being concentrated under reduced pressure. The product was isolated by flash column chromatography eluting with 0% to 10% methanol/DCM to obtain the title compound (34 mg) as white solid.

1. customquenched by the addition of 1M HCl (10 mL)
2. extractionThe mixture was extracted with ethyl acetate (3×20 mL)
3. washThe combined organic layers were washed with brine (2×10 mL)
4. concentrationbefore being concentrated under reduced pressure
5. customThe product was isolated by flash column chromatography
6. washeluting with 0% to 10% methanol/DCM