HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1643298Generated: November 3, 2026
Trifluoroacetic acid → (R)-1-(piperidin-3-ylmethyl)piperidine
https://huagongshe.com/reaction/1643298
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (S)-tert-butyl 3-(piperidin-1-ylmethyl)piperidine-1-carboxylate | HCID 59568770 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (R)-1-(piperidin-3-ylmethyl)piperidine | HCID 26966932 | — |
Reaction Steps
To a solution of the (S)-tert-butyl 3-(piperidin-1-ylmethyl)piperidine-1-carboxylate isolated above in 200 μL DCM was slowly added 2 mL TFA and the resulting solution stirred for 30 min at 25° C. The solvent was evaporated and the crude product was used directly in the next reaction without further purification. (For example, reaction with Intermediate A5 in Specific Scheme 5)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08119692B2 |
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| Source dataset | uspto-grants-2012_02 |
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| ORD ID | ord-7832b4a468f74217a2b0f49447677f8b |
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| Source note | uspto-grants-2012_02 |
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