Hydroxylamine → HCID 59568849, compound

Participants

Reaction Steps

To a solution prepared by dissolving 4-methoxy-4-o-tolyl-butyric acid methyl ester (230.0 mg, 1.03 mmol) into 3 mL of a mixture of THF, methanol, and 50 wt % NH2OH in H2O (2:2:1) was added KCN (6.0 mg, 0.03 mmol). The reaction mixture was stirred for 3 days at room temperature and then quenched by the addition of 10 mL of 1M aqueous HCl. The mixture was extracted with ethyl acetate (3×20 mL) and the combined organic layers washed with brine (2×10 mL). The product was isolated by flash column chromatography eluting with 0% to 10% methanol/DCM to afford 184 mg of the title compound as a yellow oil.

Provenance & Evidence