Hydroxylamine → HCID 59568782, compound

Participants

Reaction Steps

To a solution of 4-(4-chloro-phenyl)-4-methoxy-butyric acid methyl ester (62.5 mg, 0.25 mmol) dissolved in 2 mL of THF, methanol, and 50 wt % NH2OH in H2O (2:2:1) mixture was added KCN (4.0 mg, 0.06) and the resulting mixture stirred for 3 days at room temperature. The reaction was quenched by the addition of 1M aqueous HCl (10 mL) and the resulting mixture extracted with ethyl acetate (3×10 mL). The combined organic layers were washed with brine (2×5 mL). The product was isolated by flash column chromatography eluting with 0% to 10% methanol/DCM to give the title compound (34 mg) as colorless oil.

Provenance & Evidence