Lithium Hydroxide → HCID 8122187, compound

Participants

Reaction Steps

To a solution of methyl 4-(dibenzylamino)benzoate (52 mg, 0.16 mmol) in a 2:1 mixture of THF/dH2O was added LiOH (10 mg, 0.48 mmol). Tetra-butyl ammonium hydroxide (2 mL, 0.1N solution in toluene/MeOH) was added to the reaction and allowed to stir at room temperature for 6 hours. The solvent was concentrated in vacuo and the reaction mixture was azeotroped with MeOH several times then placed on the high vacuum for 2 hours to dry to provide the desired 4-(dibenzylamino)benzoic acid which was confirmed by MS: cal'd 318.1 (MH+), exp 318.1 (MH+).

Provenance & Evidence